Report an error   


Submitted: 15 October 2014 Modified: 29 January 2018
HERDIN Record #: NCR-ADMU-ASMPH14101505390660

Factors associated with non-adherence to tuberculosis Direct Observed Treatment Shortcourse Plus (DOTS Plus) Program in Persons with Multidrug-Resistant (MDR-TB) Tuberculosis at the Lung Center of the Philippines.

John Louis  Padayao,
Maikelli Xiphi Balazo,
Aivan Maury De Vera,
Katrina Camille  Litam,
Felicia Mikaela Solano,
Angel Luis  Veloso,
Cecilia Jimeno

See More

SETTING: Tuberculosis directly observed treatment, shortcourse (TB DOTS) clinic of the Lung Center of the Philippines, Quezon City. 


OBJECTIVES: To determine the factors associated with treatment non-adherence in TB DOTS Plus patients 18 years old and above with multidrug-resistant tuberculosis (MDR-TB).


DESIGN: A case control study. 83 MDR-TB patients were selected using a purposive sampling method. Cases were patients non-adherent to their prescribed DOTS Plus regimen and controls were patients adherent to their prescribed DOTS Plus regimen. All study subjects were individually interviewed using a guided survey questionnaire from June to August 2014.


RESULTS: Knowledge on tuberculosis and number of adverse drug reactions (ADRs) were found to be significantly associated with treatment non-adherence (OR=2.83 and OR=1.27 respectively, p<.007).


CONCLUSION: Knowledge on tuberculosis and number of ADRs experienced are significantly associated with treatment non-adherence. The pre-treatment briefing included in the LCP's TB DOTS program is effective in imparting knowledge to patients, preparing them for possible ADRs, and subsequently decreasing treatment non-adherence.

Publication Type
Research Project
Date
LocationLocation CodeAvailable FormatAvailability
Ateneo School of Medicine and Public Health Library PH Papers 2014 Fulltext Print Format (Ask the Information Officer)